The news just crossed the wire that Lisa Jackson, EPA administrator and possibly the most anti-business member of the Obama administration has resigned:
Environmental Protection Agency Administration Lisa Jackson says she's stepping down after nearly four years on the job.

Jackson announced her departure in a statement Thursday. She gave no particular reason for leaving but said she was ready for new challenges, time with her family and new opportunities to make a difference.

She says she's leaving the agency, in her words, "confident the ship is sailing in the right direction."

Jackson is expected to leave after the State of the Union address in late January. Cabinet members looking to move on often leave at the beginning of a president's second term.